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The sham surgery group (referred to as normal cartilage) was sacrificed at 12 weeks, and the only-defect groups with PBS injection (referred to as only-defect) were sacrificed at 4, 8, and 12 weeks when the injection groups were sacrificed

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Excess lipid reactive oxygen species produced during ferroptosis eventually leads to oxidative cell death

These processes collectively support the proliferative and remodeling phases of wound repair

Both BPC-157 and TB-500 have extensive independent published research bases, with additional evidence emerging from combination studies that specifically document the synergistic interactions between the two compounds